It is important to remember that epithelialization happens faster when wounds are kept moist and hydrated.
![fhe 12 stages of healing fhe 12 stages of healing](https://i.ytimg.com/vi/JYrPYlEfYhM/hqdefault.jpg)
In the final phase of the proliferative stage of wound healing, epithelial cells resurface the injury. Dark granulation tissue can be a sign of infection, ischemia, or poor perfusion. Moreover, healthy granulation tissue does not bleed easily. In healthy stages of wound healing, granulation tissue is pink or red and uneven in texture. Myofibroblasts cause the wound to contract by gripping the wound edges and pulling them together using a mechanism similar to that of smooth muscle cells. In addition, a new network of blood vessels must be constructed so that the granulation tissue can be healthy and receive sufficient oxygen and nutrients. In the proliferative phase, the wound contracts as new tissues are built. The proliferative phase of wound healing is when the wound is rebuilt with new tissue made up of collagen and extracellular matrix. Inflammation is a natural part of the wound healing process and only problematic if prolonged or excessive.
![fhe 12 stages of healing fhe 12 stages of healing](https://d3525k1ryd2155.cloudfront.net/h/830/859/1297859830.1.x.jpg)
These white blood cells, growth factors, nutrients and enzymes create the swelling, heat, pain and redness commonly seen during this stage of wound healing. During the inflammatory phase, damaged cells, pathogens, and bacteria are removed from the wound area.
![fhe 12 stages of healing fhe 12 stages of healing](https://epienergetics.com/wp-content/uploads/2020/06/12stages-transparent.png)
The fluid engorgement allows healing and repair cells to move to the site of the wound. Inflammation both controls bleeding and prevents infection. Inflammation is the second stage of wound healing and begins right after the injury when the injured blood vessels leak transudate (made of water, salt, and protein) causing localized swelling. The thrombus is generally important in the stages of wound healing but becomes a problem if it detaches from the vessel wall and goes through the circulatory system, possibly causing a stroke, pulmonary embolism or heart attack. The formation of a thrombus or clot keeps the platelets and blood cells trapped in the wound area. As the fibrin mesh begins, the blood is transformed from liquid to gel through pro-coagulants and the release of prothrombin. After that, the first fibrin strands begin to adhere in about sixty seconds. The platelets adhere to the sub-endothelium surface within seconds of the rupture of a blood vessel's epithelial wall. The hemostasis stage of wound healing happens very quickly.
![fhe 12 stages of healing fhe 12 stages of healing](https://i.etsystatic.com/24891410/r/il/23134f/2665988267/il_570xN.2665988267_4iee.jpg)
Finally, coagulation occurs and reinforces the platelet plug with threads of fibrin which are like a molecular binding agent. Next, platelets stick together in order to seal the break in the wall of the blood vessel. The first step of hemostasis is when blood vessels constrict to restrict the blood flow. Hemostasis starts when blood leaks out of the body. Hemostasis is the process of the wound being closed by clotting. The four stages of wound healing are: Hemostasis Phase Although the stages of wound healing are linear, wounds can progress backward or forward depending on internal and external patient conditions. The stages of wound healing proceed in an organized way and follow four processes: hemostasis, inflammation, proliferation and maturation.